Practice practice practice!
What are your findings?
How would this change management?
Try not to cheat!
Some articles and other resources:
The Seminars in Neuropsychiatry has moved to: www.eratne.net/seminars
Click here for the full list of publications on PubMed (currently only first author displays below, unfortunately)
- CONCLUSIONS: This is the largest cohort of NPC patients investigated for ocular-motor function. Vertical supranuclear saccade palsy is the hallmark of NPC. Vertical upward and downward saccades are equally impaired. Horizontal saccadic peak velocity and latency, vertical saccadic duration and amplitude, and horizontal position smooth pursuit can be used as surrogate parameters for clinical trials. Compensating strategies can contribute in establishing a diagnosis.
- Psychiatric and cognitive characteristics of older adults admitted to a Video-EEG monitoring (VEM) unitCONCLUSION: Psychiatric comorbidities are common among older adults admitted for VEM. The psychological impact of epilepsy and risk factors for PNES seen in younger patients are also applicable in the older group. The older group demonstrated more cognitive impairments than the younger group, although these were usually unrecognized by individuals. Older adults admitted to VEM will benefit from psychiatric and neuropsychological input to ensure a comprehensive care approach to evaluation and…
- Pathophysiology and management of neuropsychiatric symptoms in succinic semialdehyde dehydrogenase deficiencyNo abstract
- Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysisCONCLUSIONS AND RELEVANCE: This study provides evidence for widespread subtle, lower CT measures in individuals at CHR. The pattern of CT measure differences in those in the CHR-PS+ group was similar to those reported in other large-scale investigations of psychosis. Additionally, a subset of these regions displayed abnormal age associations. Widespread disruptions in CT coupled with abnormal age associations in those at CHR may point to disruptions in postnatal brain developmental processes.
- The Three Glycotypes in the London Classification System of Sporadic Creutzfeldt-Jakob Disease Differ in Disease DurationSporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of CJD and is believed to be caused by the misfolding and aggregation of endogenous prion protein. Several classification systems have been developed to correlate the molecular characteristics of these misfolded prions (PrP^(Sc)) to the heterogeneous clinical presentations of sCJD. A central component of these systems is glycotyping, which involves the interpretation of the results of western immunoblotting of the…
- Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson's diseaseThis study seeks a better understanding of possible pathophysiological mechanisms associated with cognitive impairment and dementia in Parkinson's disease using structural and functional MRI. We investigated resting-state functional connectivity of important subdivisions of the caudate nucleus, putamen and thalamus, and also how the morphology of these structures are impacted in the disorder. We found cognitively unimpaired Parkinson's disease subjects (n = 33), compared to controls (n = 26),…
- Brain hypometabolic changes in 14 adolescent-adult patients with Niemann-Pick disease type C assessed by 18F-fluorodeoxyglucose positron emission tomographyCONCLUSIONS: We found bilateral symmetric hypometabolism of the frontal lobes, thalami and parietal lobes (especially posterior cingulate gyrus) to be typical of adolescent-adult NPC. Ataxia was commonly associated with cerebellar or thalamic hypometabolism. Frontal lobe hypometabolism showed the best inverse correlation with clinical severity.
- Objective: People with neurocognitive disorders (NCDs) have an increased risk of epilepsy. However, most studies investigating the risk of seizures in people with NCDs are limited to those with Alzheimer's disease (AD) and vascular dementia (VD), and those who developed dementia after age 65 years. A knowledge gap exists regarding factors associated with development of epilepsy in people with younger-onset NCD, and those with non-AD and non-VD dementia subtypes. In this study, we aimed to…
- CONCLUSIONS: Inclusion of genetic testing in the diagnostic pathway in some patients with dementia could potentially reduce the time taken to diagnose the cause of their dementia. Although a definite advantage as an addition to the diagnostic repository, genetic testing has many pros and cons which need to be carefully considered first.
- Odor Identification Testing Can Assist in the Clinical Distinction Between Psychiatric Disorders and Neurological/Neurodegenerative DisordersCONCLUSIONS: Patients with neuropsychiatric difficulties who score 8 or less on Sniffin' Sticks are more likely to have a neurodegenerative illness. A cut-off score of 8 is potentially a "red flag" for clinicians faced with the diagnostic question of PPD versus NND.
RMH-Alfred-Concord and RANZCP VIC Section of Neuropsychiatry
Seminars in Neuropsychiatry
Dates set for 2021!
Neuropsychiatry at the Royal Melbourne, Alfred and Concord Hospitals, and the RANZCP Victorian Section of Neuropsychiatry, are pleased to have several seminars planned for 2021. Please spread the word to colleagues far and wide with this link: www.eratne.net/seminars
To receive details on how to attend sessions, for any queries, feedback, to suggest potential future topics, and to be put on the email list, please contact us.
Save the dates for these upcoming seminars, 8-9am (AEST/Melbourne time) on the following Tuesdays:
6 April: A/Professor Andrew Evans, neurologist at Neuropsychiatry RMH, and head of movement disorders RMH: The Neurological Examination
11 May: Dr Nicola Warren – Autoimmune encephalitis: how should we screen, diagnose and treat?
15 June: Dr Samantha Loi – Younger Onset Dementia
20 July: Topic and speaker TBC
31 August: Professor Harry McConnell – Neuropsychiatry of Epilepsy
5 October: Topic and speaker TBC
7 December: Topic and speaker TBC
Dr Dhamidhu Eratne
Dr Toby Winton-Brown
Dr Andrew Gleason
Professor Dennis Velakoulis
on behalf of the RANZCP Section of Neuropsychiatry Victorian Subcommittee
We hope you’ve enjoyed our RMH-Alfred Neuropsychiatry Education Series this year, and we look forward to seeing you next year.
– Dhamidhu Eratne, Toby Winton-Brown, Dennis Velakoulis, and many others, on behalf of the Section of Neuropsychiatry and Royal Melbourne Hospital and the Alfred
Thank you to all our excellent speakers for their time, and special mention and thanks to Kate Egan, Nicholas Burgess, and Lily Ward for keeping the lecture series afloat.
Now it’s feedback time!
Please go to this website to give us some (anonymous) feedback:
This research and clinically focussed event promises to offer a broad overview of current issues in genetics in neurodegenerative disorders, and should be of interest to a wide range of clinicians, researchers and scientists in the neurosciences.
Ticketing has been reopened!
Register now via this Eventbrite link: https://bit.ly/2Y3CJjz
Please contact Dr Dhamidhu Eratne (firstname.lastname@example.org) if you have any queries.
Programme and Speakers:
Monday 12 August, 1400-1730
Venue TBC at MCRI/RCH – trying to get larger venue
1400-1500 Glenda Halliday (confirmed) – opening plenary – “Overview of neurodegenerative genetics and why NGS is needed”
1500-1520 (15min + 5min for questions) Dhamidhu Eratne (confirmed) – “WES, What is it Good for (in Neurodegenerative Disorders)? Updates from the Melbourne Genomics Complex Neurology Flagship”
1520-1540 (15min + 5min for questions) Martin Delatycki and David Szmulewicz (confirmed) – “Genetic ataxia- what is the latest about aetiology and treatment?”
1600-1620 (15min + 5min for questions) Aamira Huq (confirmed) – “The Paradox of the Young Demented and the Old Resilient – Can Genetics Explain?”
1620-1640 (15min + 5min for questions) Melanie Bahlo (confirmed) – “Repeat Expansion Detection from NGS Data for Neurodegenerative Disorders”
1640-1700 (15min + 5min for questions) Sam Berkovic (confirmed) – “Genetics in Epilepsy”
1700-1730 (20-25 + 5-10min for questions) Steve Petrou (confirmed) – “The Promise of Antisense Oligonucleotide Therapy in Neurogenetic Disorders”